Organic letters

Tandem thiol switch synthesis of peptide thioesters via N–S acyl shift on thiazolidine

RK Sharma, JP Tam

文献索引：Sharma, Rohit K.; Tam, James P. Organic Letters, 2011 , vol. 13, # 19 p. 5176 - 5179

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被引用次数: 17

摘要

An efficient “thiol switch” approach for the synthesis of peptide thioesters via an acid- catalyzed N–S acyl shift and a thioester exchange reaction in tandem with concurrent removal of protecting groups is described. This method employs novel 2-(thiomethyl)