A Substrate??Driven Approach to Determine Reactivities of α, β??Unsaturated Carboxylic Esters Towards Asymmetric Bioreduction
…, WMF Fabian, M Hall, K Ditrich, K Faber
文献索引：Tasnadi, Gabor; Winkler, Christoph K.; Clay, Dorina; Sultana, Nargis; Fabian, Walter M. F.; Hall, Melanie; Ditrich, Klaus; Faber, Kurt Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10362 - 10367
Abstract The degree of C [DOUBLE BOND] C bond activation in the asymmetric bioreduction of α, β-unsaturated carboxylic esters by ene-reductases was studied, and general recommendations to render these “borderline-substrates” more reactive towards enzymatic reduction are proposed. The concept of “supported substrate activation” was developed. In general, an additional α-halogenated substituent proved to be beneficial for enzymatic ...
