Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

T Yamane, K Makino, N Umezawa…

文献索引：Yamane, Takehiro; Makino, Kohei; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko Angewandte Chemie - International Edition, 2008 , vol. 47, # 34 p. 6438 - 6440

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被引用次数: 19

摘要

Cytochrome P450s catalyze various types of oxidative reactions involved in steroid biosynthesis, the metabolism of fatty acids, and the detoxification of xenobiotic compounds.[1] Most of the reactions are monooxygenase-type NADPH/NADH-and O2- dependent ones, but when the endoperoxide (EP) isomerizing P450 works as a prostacyclin synthase or thromboxane synthase it is neither NADPH/NADH-nor O2-dependent, and is ...