Structure–activity relationship studies of pyrazolo [3, 4-d] pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and …
LL Yang, GB Li, S Ma, C Zou, S Zhou…
文献索引：Garofalo, Antonio; Farce, Amaury; Ravez, Severine; Lemoine, Amelie; Six, Perrine; Chavatte, Philippe; Goossens, Laurence; Depreux, Patrick Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1189 - 1204
... Journal of Medicinal Chemistry. ... are found in up to one-third of AML cases; the most prevalent activating mutations are “internal tandem duplications” (ITDs) in the juxtamembrane domain that lead to constitutive, ligand-independent activation of the kinase.(6-8) Numerous ...
