e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Structure–activity relationship studies of pyrazolo [3, 4-d] pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and …
... Journal of Medicinal Chemistry. ... are found in up to one-third of AML cases; the most prevalent activating mutations are “internal tandem duplications” (ITDs) in the juxtamembrane domain that lead to constitutive, ligand-independent activation of the kinase.(6-8) Numerous ...
