Synthesis, crystal structure and β-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1, 2, 4-triazole derivatives

…, NH Rama, S Noreen, MI Choudhary, PG Jones…

文献索引：Hanif, Muhammad; Khan, Imtiaz; Rama, Nasim Hasan; Noreen, Shagufta; Choudhary, Muhammad Iqbal; Jones, Peter G.; Iqbal, Mazhar Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3885 - 3896

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被引用次数: 8

摘要

Abstract A new series of hydrazinecarboxamides (5a–n), bearing various methoxyphenyl and methoxyphenethyl groups, was synthesized by condensation of corresponding acid hydrazides (3a–f) with methoxyphenylisocyanates (4a–c). Dehydrocyclization of hydrazinecarboxamides (5a–n) yielded corresponding methoxyphenyl and methoxyphenethyl substituted triazoles (6a–l) by refluxing in 2 N aqueous sodium ...