Nonpeptide αvβ3 antagonists. Part 11: discovery and preclinical evaluation of potent αvβ3 antagonists for the prevention and treatment of osteoporosis

PJ Coleman, KM Brashear, BC Askew…

文献索引：Journal of medicinal chemistry, , vol. 47, # 20 p. 4829 - 4837

被引用次数: 75

摘要

... Journal of Medicinal Chemistry. ... Departments of Medicinal Chemistry, Bone Biology and Osteporosis Research, Drug Metabolism and Pharmacology, and Molecular Systems, Merck Research Laboratories, West Point, Pennsylvania 19486. J. Med. Chem. ... Chemistry. ...

6272-26-0

6-羟基-2H-苯并呋喃-3-酮

~53%

Discovery and development of potent LFA-1/ICAM-1 antagonist ...

[Zhong, Min; Gadek, Thomas R.; Bui, Minna; Shen, Wang; Burnier, John; Barr, Kenneth J.; Hanan, Emily J.; Oslob, Johan D.; Yu, Chul H.; Zhu, Jiang; Arkin, Michelle R.; Evanchik, Marc J.; Flanagan, W. Mike; Hoch, Ute; Hyde, Jennifer; Prabhu, Saileta; Silverman, Jeffrey A.; Wright, Jasmin ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 203 - 206]

Transition metal directed synthesis of moracin M, a phytoale...

[Mann, Inderjit S.; Widdowson, David A.; Clough, John M. Tetrahedron, 1991 , vol. 47, # 37 p. 7981 - 7990]

Concise and Efficient Synthesis of Linear Furocoumarins: Pso...

[Zhang, Bang-Le; Wang, Fang-Dao; Yue, Jian-Min Synlett, 2006 , # 4 p. 567 - 570]

Syntheses of 5-and 6-[2, 3]-dihydrobenzofuran β-amino acids

[Tetrahedron Letters, , vol. 41, # 31 p. 5803 - 5806]

Concise Synthesis of 6-Cyanobenzo [b] furan, a Useful Buildi...

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