Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones
SE Webber, TM Bleckman, J Attard…
文献索引：Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746
... By using a high-resolution crystal structure and mo- lecular modeling techniques, initial design work led to the synthesis of four different quinazolinones, each substituted 0 1993 American Chemical Society ... Page 4. 736 Journal of Medicinal Chemistry, 1993, Vol. ...
