Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

SE Webber, TM Bleckman, J Attard…

Index: Journal of Medicinal Chemistry, , vol. 36, # 6 p. 733 - 746

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Citation Number: 156

Abstract

... By using a high-resolution crystal structure and mo- lecular modeling techniques, initial design work led to the synthesis of four different quinazolinones, each substituted 0 1993 American Chemical Society ... Page 4. 736 Journal of Medicinal Chemistry, 1993, Vol. ...