Abstract Our ongoing effort towards the development of highly selective transition-metal- catalysed C–H activation processes has led to the expansion of the Catellani reaction. In a Pd 0/Pd II/Pd IV-catalysed domino reaction, an aryl iodide, alkyl iodide and tert-butyl acrylate were combined to synthesize the carbon framework of the novel lignan (+)-linoxepin. The enantioselective synthesis highlights the work accomplished in our group and provides an ...
