Substituted heteroaromatic compounds: effect on nicotine self-administration in rats

JR Cashman, K Okolotowicz, M Cerny, R Johnson…

文献索引：Cashman, John R.; Okolotowicz, Karl; Cerny, Matt; Johnson, Robert; Janowsky, Aaron; Azar, Marc R. Psychopharmacology, 2012 , vol. 221, # 4 p. 637 - 648

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被引用次数: 1

摘要

Abstract Rationale Certain compounds that nonselectively inhibit a prominent human nicotine-metabolizing enzyme (ie, human cytochrome P-450 2A6, hCYP 2A6) showed inhibition of smoking in humans. However, a comprehensive examination of hCYP 2A6 inhibitors to decrease nicotine self-administration in rats has not been reported. Objectives We tested substituted heteroaromatic compounds designed to selectively inhibit hCYP ...

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