Heme Oxygenase Inhibition by α??(1H??Imidazol??1??yl)?螃佝?phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker

…, G Roman, D Vukomanovic, K Nakatsu…

文献索引：Vlahakis, Jason Z.; Lazar, Carmen; Roman, Gheorghe; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A. ChemMedChem, 2012 , vol. 7, # 5 p. 897 - 902

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被引用次数: 11

摘要

Abstract Several α-(1H-imidazol-1-yl)-ω-phenylalkanes were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds were found to be potent and selective for the stress-induced isozyme HO-1, showing mostly weak activity toward the constitutive isozyme HO-2. The introduction of an oxygen atom in the alkyl linker produced analogues with decreased potency toward HO-1, whereas the presence of a sulfur atom in ...