Synthesis and antitumor activity of a heterodinucleotide of BVDU and gemcitabine

…, P Franchetti, P Vita, R Petrelli, M Grifantini

文献索引：Cappellacci; Franchetti; Vita; Petrelli; Grifantini Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 5 p. 460 - 468

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被引用次数: 4

摘要

A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5′, 5′- pyrophospate bridge (BVDUp2dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp2dFdC showed a cytotoxicity similar to that of Gemcitabine.