Bioorganic chemistry

Concerning two-metal cooperativity in model phosphate hydrolysis

M Leivers, R Breslow

文献索引：Leivers, Martin; Breslow, Ronald Bioorganic Chemistry, 2001 , vol. 29, # 6 p. 345 - 356

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被引用次数: 27

摘要

Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.