Bioorganic chemistry

Concerning two-metal cooperativity in model phosphate hydrolysis

M Leivers, R Breslow

Index: Leivers, Martin; Breslow, Ronald Bioorganic Chemistry, 2001 , vol. 29, # 6 p. 345 - 356

Full Text: HTML

Citation Number: 27

Abstract

Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.