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Design, synthesis, and biological evaluation of simplified α-Keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of …

…, J Desharnais, A Tavassoli, Y Zhang, IA Wilson…

文献索引:Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501

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被引用次数: 26

摘要

A series of simplified α-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues lacking the benzoylglutamate subunit were prepared and examined as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase).

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