Design, Synthesis and Quantitative Structure-Activity Relationship Study of N-(3-Oxo-3, 4-dihydro-2H-benzo (1, 4) oxazine-7-carbonyl) guanidine Derivatives as …
T Yamamoto, M Hori, I Watanabe, H TSUTSUI…
文献索引：Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Tsutsui, Hisayoshi; Harada, Kengo; Ikeda, Shoji; Maruo, Joji; Morita, Tominori; Ohtaka, Hiroshi Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1975 - 1983
Inhibitiion of the Na/H exchanger is promising approach for treating ischemia-reperfusion injury, but no clinical agent is yet available. Recently, we established the structural requirements for potent inhibitors of the Na/H exchanger. In the present work, we designed N-(3-oxo-3, 4-dihydro-2H-benzo [1, 4] oxazine-7-carbonyl) guanidine 3a as a new lead compound for potent inhibitors with good water-solubility, based on the previous ...
