Tetrahedron: Asymmetry

Acylase I in the alcoholysis of α-substituted dicarboxylic acid esters and derivatives: enantio-and regioselectivity

A Liljeblad, J Lindborg, LT Kanerva

文献索引：Liljeblad, Arto; Lindborg, Jutta; Kanerva, Liisa T. Tetrahedron Asymmetry, 2000 , vol. 11, # 19 p. 3957 - 3966

全文：HTML全文

被引用次数: 16

摘要

Enantio-and regioselective butanolyses of α-substituted dimethyl succinates (substituents: Me, MeO2CCH2, NH2, AcHN, PrCOHN, HO, MeO, PrO, AcO, PrCO2, HepCO2, Cl and Br) and glutarates (substituents: PrCONH and CbzNH) and that of methyl pyroglutamate with acylase I enzymes have been studied. Acylase I-catalyzed reactions were totally regioselective proceeding exclusively at the sterically more ...