Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

…, K Beebe, L Neckers, N Winssinger

文献索引：Garcia, Jose; Barluenga, Sofia; Beebe, Kristin; Neckers, Len; Winssinger, Nicolas Chemistry - A European Journal, 2010 , vol. 16, # 32 p. 9767 - 9771

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被引用次数: 13

摘要

CubØ resin has been known since the 1850s [1] to contain active ingredients useful as pesticides and insecticides.[2] Fractionation of the active ingredients has led to the isolation of biosynthetically related flavonoids and rotenoids which have been reisolated from various botanical sources.[3] The most prominent and active ingredients are rotenone, deguelin and tephrosin (Figure 1). The toxic properties of rotenone were originally ascribed to its ...