Studies towards the Total Synthesis of (–)??Caulerpenynol, a Toxic Sesquiterpenoid of the Green Seaweed Caulerpa taxifolia

L Commeiras, J Thibonnet…

文献索引：Commeiras, Laurent; Thibonnet, Jerome; Parrain, Jean-Luc European Journal of Organic Chemistry, 2009 , # 18 p. 2987 - 2997

全文：HTML全文

被引用次数: 6

摘要

Abstract The first diastereoselective synthesis of the antimicrobial and cytotoxic agent (–)- caulerpenynol (2) was achieved in relatively few steps from commercially available (S)-malic acid. Highlights of this synthesis include the nonracemization of the sensitive α-hydroxy ketone moiety and the proper choice of the protecting groups for critical last deprotection step.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)