Chemistry of N-nitroso compounds. 1. Synthesis and stereodynamics of N-nitrosopiperidines and N-nitrosopiperidin-4-ones

T Ravindran, R Jeyaraman, RW Murray…

文献索引：Ravindran, Thiruvenkadam; Jeyaraman, Ramasubbu; Murray, Robert W.; Singh, Megh Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4833 - 4840

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被引用次数: 72

摘要

Many nitrosamines are known to be carcinogenic.'It has also been shown that blocking of the positions a to the ring nitrogen atom by methyl groups in cyclic nitrosamines reduces the carcinogenic activity. 2 The alkyl cation formed from the nitrosamine (Scheme I) is believed to be responsible for the initial step in the process of carcinogenesis by alkylating cellular components and DNA base~.~,'The first step in the formation of this alkyl cation involves ...