Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo [5, 4-d] pyrimidines

B Singh, SK Guru, S Kour, SK Jain, R Sharma…

文献索引：Singh, Baljinder; Guru, Santosh K.; Kour, Smit; Jain, Shreyans K.; Sharma, Rajni; Sharma, Parduman R.; Singh, Shashank K.; Bhushan, Shashi; Bharate, Sandip B.; Vishwakarma, Ram A. European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 864 - 874

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被引用次数: 11

摘要

Abstract Thiazolo [5, 4-d] pyrimidines are important class of heterocyclic compounds possessing diverse range of biological activities. Herein, we report an efficient synthesis of thiazolo [5, 4-d] pyrimidines using recyclable KF/alumina catalyst. The reaction of 4, 6- dichloro-5-aminopyrimidine with isothiocyanates in presence of 20 mol% KF/alumina produced thiazolo [5, 4-d] pyrimidines in excellent yields without any chromatographic ...