Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

…, J Du Ha, SS Kim, SK Kang, DG Jeong, SK Jung…

文献索引：Ahn, Jin Hee; Kim, Seung Jun; Park, Woul Seong; Cho, Sung Yun; Ha, Jae Du; Kim, Sung Soo; Kang, Seung Kyu; Jeong, Dae Gwin; Jung, Suk-Kyeong; Lee, Sang-Hyeup; Kim, Hwan Mook; Park, Song Kyu; Lee, Ki Ho; Lee, Chang Woo; Ryu, Seong Eon; Choi, Joong-Kwon Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2996 - 2999

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被引用次数: 99

摘要

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.