Tetrahedron letters

Palladium catalyzed α-arylation of methyl isobutyrate and isobutyronitrile: an efficient synthesis of 2, 5-disubstituted benzyl alcohol and amine intermediates

R Shetty, KK Moffett

文献索引：Shetty, Rupa; Moffett, Kristofer K. Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8021 - 8024

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被引用次数: 6

摘要

Several 2, 5-disubstituted benzyl alcohols containing a functionalized t-butyl moiety were synthesized via palladium catalyzed α-arylation of methyl isobutyrate and butyronitrile on synthetically useful scales. The resulting benzyl alcohols could then be further elaborated to benzyl amines or other desirable intermediates.