Tetrahedron Letters

Oxidative fragmentation of bicyclic hydroxy silanes and stannanes: a strategy for the stereoselective synthesis of kainoids

J Clayden, KR Hebditch, B Read, M Helliwell

文献索引：Clayden, Jonathan; Hebditch, Katherine R.; Read, Benjamin; Helliwell, Madeleine Tetrahedron Letters, 2007 , vol. 48, # 48 p. 8550 - 8553

全文：HTML全文

被引用次数: 6

摘要

The addition of tin or silicon nucleophiles to bicyclic enones generated by dearomatising cyclisation gives stannanes and silanes stereoselectively. These compounds may be fragmented under oxidative conditions to generate substituted pyrrolidines bearing C2 and C3 substituents closely related to those found in the kainoid series of cyclic amino acids.