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A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acid-free conditions

…, EH Lee, S Chaysripongkul, W Chavasiri, DO Jang

文献索引:Kang, Dong Ho; Joo, Tae Young; Lee, Eun Hwa; Chaysripongkul, Skaydaw; Chavasiri, Warinthorn; Jang, Doo Ok Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5693 - 5696

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被引用次数: 19

摘要

Acid bromides were prepared efficiently from carboxylic acids with readily available ethyl tribromoacetate and triphenylphosphine at room temperature under neutral conditions. The present process is applicable to the preparation of various acid bromides from aromatic and aliphatic carboxylic acids. Aromatic carboxylic acids were found to be more reactive than aliphatic carboxylic acids under reaction conditions.

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