Organic letters

Palladium-catalyzed domino C–S coupling/carbonylation reactions: An efficient synthesis of 2-carbonylbenzo [b] thiophene derivatives

F Zeng, H Alper

文献索引：Zeng, Fanlong; Alper, Howard Organic Letters, 2011 , vol. 13, # 11 p. 2868 - 2871

被引用次数: 45

摘要

A facile and selective palladium-catalyzed domino procedure has been developed for the preparation of 2-carbonylbenzo [b] thiophene derivatives from 2-gem-dihalovinylthiophenols . This protocol involves intramolecular C–S coupling/intermolecular carbonylation cascade sequences and allows access to various highly functionalized benzo [b] thiophenes in moderate yields.

~65%

~50%

~56%

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