Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure− activity relationships, and …

H Guo, H Shao, Z Yang, S Xue, X Li, Z Liu…

文献索引：Guo, Hui-Fang; Shao, Hua-Yi; Yang, Zhao-Yong; Xue, Si-Tu; Li, Xue; Liu, Zong-Ying; He, Xiao-Bo; Jiang, Jian-Dong; Zhang, Yue-Qin; Si, Shu-Yi; Li, Zhuo-Rong Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1819 - 1829

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被引用次数: 36

摘要

In this work, substituted benzothiophene and benzofuran compounds were found to be a new class of potential anabolic agents by enhancing BMP-2 expression. A series of benzothiophene and benzofuran derivatives have been synthesized, and their activities of up-regulating BMP-2 and bone loss prevention efficacies in SAMP6 mice and OVX rats have been studied. Benzothiophenes 1, 3, 14, 4a, 7a, 8a, and benzofuran analogue 2 showed ...