Synthesis of prostaglandin synthetase substrate analogs. 2.(8Z, 11Z, 14Z)-15-Methyl-8, 11, 14-eicosatrienoic acid

MI Dawson, M Reid, ME Hemler…

文献索引：Dawson,M.I. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 1396 - 1400

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被引用次数: 4

摘要

The essential fatty acids,(82,112,142)-8, 11, 14-eicosatrienoic acid and arachidonic acid, are converted to the prostaglandins El and Ez, respectively, by a multistage biosynthetic process catalyzed by the enzyme prostaglandin synthetase. As part of a program to prepare substrate analogues of these acids with potential prostaglandin synthetase inhibitory activity, we have synthesized (82,112,142)-15-methy1-8, 11, 14-eicosatrienoic acid (l).'This ...