Utilization of tetrabutylammonium triphenylsilyldifluoride as a fluoride source for nucleophilic fluorination

AS Pilcher, HL Ammon, P DeShong

文献索引：Pilcher, Anthony S.; Ammon, Herman L.; DeShong, Philip Journal of the American Chemical Society, 1995 , vol. 117, # 18 p. 5166 - 5167

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被引用次数: 196

摘要

Over the past several decades, a growing number of fluorinated drugs have found use in medical applications including cardiovascular, central nervous system, anticancer, antibacterial, and antiviral therapies.'Medicinal chemists frequently use fluorine to modify the properties of a potential drug. While replacement of a hydrogen with fluorine does not alter the steric size of a molecule, it provides for increased lipophilicity, hydrogen bonding, and ...