European journal of medicinal chemistry

Synthesis and anticancer activity of novel 2-pyridyl hexahyrocyclooctathieno [2, 3-d] pyrimidine derivatives

AE Kassab, EM Gedawy

文献索引：Kassab, Asmaa E.; Gedawy, Ehab M. European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 224 - 230

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被引用次数: 30

摘要

A series of new 2-pyridyl hexahydrocycloocta [4, 5] thieno [2, 3-d] pyrimidines with different substituents as C-4 position was synthesized. The anticancer activity of the newly synthesized compounds was tested in vitro using a two-stage process utilizing 60 different human tumor cell lines representing leukemia, melanoma and cancers of lung, colon, central nervous system, ovary, kidney, prostate as well as breast. Compounds 4a, 6a, 7a, ...