Development of antimycobacterial tetrahydrothieno [2, 3-c] pyridine-3-carboxamides and hexahydrocycloocta [b] thiophene-3-carboxamides: Molecular modification …

R Nallangi, G Samala, JP Sridevi, P Yogeeswari…

文献索引：Nallangi, Radhika; Samala, Ganesh; Sridevi, Jonnalagadda Padma; Yogeeswari, Perumal; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 110 - 117

全文：HTML全文

被引用次数: 5

摘要

Abstract Twenty derivatives of 2, 6-disubstituted 4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridine-3- carboxamide and ten of 2-substituted 4, 5, 6, 7, 8, 9-hexahydrocycloocta [b] thiophene-3- carboxamide were synthesized by molecular modification of a known antimycobacterial molecule. Compounds were evaluated in vitro against Mycobacterium tuberculosis (MTB), and cytotoxicity against RAW 264.7 cell line. Among the compounds, 2-(4- ...