Noncataleptic neuroleptic agents: 4-Substituted 1-(2-chloro-7-fluoro-10, 11-dihydrodibenzo [b, f] thiepin-10-yl) piperazines and related compounds

M Protiva, J Jílek, I Červená, J Pomykáček…

文献索引：Protiva, Miroslav; Jilek, Jiri; Cervena, Irena; Pomykacek, Josef; Bartl, Vaclav; et al. Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2598 - 2616

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被引用次数: 7

摘要

Abstract 1-(2-Chloro-7-fluoro-10, 11-dihydrodibenzo [b, f] thiepin-10-yl) piperazine (VI) was used to prepare a new group of potential noncataleptic neuroleptic agents. Addition of acrylonitrile and acrylamide gave the nitrile VII and the amide X. Further transformations of the nitrile VII led to the phenone VIII and the amidoxime IX. Alkylations of compound VI with 2-(2-chloroethyl)-1, 3-dioxolane and 2-(2-chloroethyl)-1, 3-dioxane resulted in the cyclic ...