Noncataleptic neuroleptic agents: 4-Substituted 1-(2-chloro-7-fluoro-10, 11-dihydrodibenzo [b, f] thiepin-10-yl) piperazines and related compounds

M Protiva, J Jílek, I Červená, J Pomykáček…

Index: Protiva, Miroslav; Jilek, Jiri; Cervena, Irena; Pomykacek, Josef; Bartl, Vaclav; et al. Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2598 - 2616

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Citation Number: 7

Abstract

Abstract 1-(2-Chloro-7-fluoro-10, 11-dihydrodibenzo [b, f] thiepin-10-yl) piperazine (VI) was used to prepare a new group of potential noncataleptic neuroleptic agents. Addition of acrylonitrile and acrylamide gave the nitrile VII and the amide X. Further transformations of the nitrile VII led to the phenone VIII and the amidoxime IX. Alkylations of compound VI with 2-(2-chloroethyl)-1, 3-dioxolane and 2-(2-chloroethyl)-1, 3-dioxane resulted in the cyclic ...