Chemical and enzymatic resolution of (R, S)-N-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine

A Goswami, JM Howell, EY Hua…

文献索引：Organic Process Research and Development, , vol. 5, # 4 p. 415 - 420

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被引用次数: 32

摘要

... Organic Process Research & Development. ... Using the repeated esterification procedure (S)-N-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine 1 was obtained in 32% yield ... Our process involved lipase PS/PP enzyme-catalyzed esterification of (R,S)-alcohol 4 with succinic ...