Chemical and enzymatic resolution of (R, S)-N-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine

A Goswami, JM Howell, EY Hua…

Index: Organic Process Research and Development, , vol. 5, # 4 p. 415 - 420

Full Text: HTML

Citation Number: 32

Abstract

... Organic Process Research & Development. ... Using the repeated esterification procedure (S)-N-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine 1 was obtained in 32% yield ... Our process involved lipase PS/PP enzyme-catalyzed esterification of (R,S)-alcohol 4 with succinic ...