A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1, 2- dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set- up was employed to significantly speed up the optimization of the reaction conditions and ...
