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The evolution of an amine dehydrogenase biocatalyst for the asymmetric production of chiral amines

MJ Abrahamson, JW Wong…

文献索引:Advanced Synthesis and Catalysis, , vol. 355, # 9 p. 1780 - 1786

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被引用次数: 29

摘要

... Advanced Synthesis & Catalysis. ... ω-transaminase to produce sitagliptin.5,6 Biocatalysis is emerging as an essential tool in the asymmetric synthesis of chiral ... The production of chiral amines remains difficult through traditional chemical catalysis,3,14 and the direct amination of ...