Structure–activity relationship of brominated 3-alkyl-5-methylene-2 (5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and …

…, J Levin, JC Janssens, A De Weerdt, J Balzarini…

文献索引：Steenackers, Hans P.; Levin, Jeremy; Janssens, Joost C.; Weerdt, Ami De; Balzarini, Jan; Vanderleyden, Jos; De Vos, Dirk E.; De Keersmaecker, Sigrid C. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5224 - 5233

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被引用次数: 38

摘要

A library of 25 1′-unsubstituted and 1′-bromo or 1′-acetoxy 3-alkyl-5-methylene-2 (5H)- furanones and two 3-alkylmaleic anhydrides was synthesized using existing and new methods. This library was tested for the antagonistic effect against the biofilm formation by Salmonella Typhimurium and the quorum sensing regulated bioluminescence of Vibrio harveyi. The length of the 3-alkyl chain and the bromination pattern of the ring structure ...