Tetrahedron letters

Open air palladium catalyzed cyanation—the use of PMHS to protect from oxygen

MT Martin, B Liu, BE Cooley, JF Eaddy

文献索引：Martin, Michael T.; Liu, Bing; Cooley Jr., Bobby E.; Eaddy, John F. Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2555 - 2557

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被引用次数: 48

摘要

PMHS (polymethylhydrosiloxane) used in catalytic amounts has a remarkable ability to prevent catalyst poisoning by oxygen contamination during palladium catalyzed cyanation reactions. The procedure is applicable to a wide range of substrates and is so effective that it allows the reactions to be run fully open to the atmosphere.