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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Design of 2, 5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo [1, 5-a] pyrimidine (NBI 30775/R121919) and structure-activity relationships of a …

C Chen, C Chen, KM Wilcoxen, CQ Huang…

文献索引：Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798

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被引用次数: 107

摘要

... Journal of Medicinal Chemistry. ... 15 Therefore, it is very difficult to develop these compounds into pharmaceutical agents for clinical usage. For example, 1 has a very long half-life (51 h) associated with high volume distribution (105 L/kg) in rats. ...

N,N,4-trimethylpyridin-2-amine结构式

N,N,4-trimethyl...

~%

6-(二甲基氨基)-4-甲基烟醛结构式

6-(二甲基氨基)-4-甲基烟醛

5-溴-2-(N,N-二甲基-1-)吡啶结构式

5-溴-2-(N,N-二甲基-1-)吡啶

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

~%

6-(二甲基氨基)烟碱醛结构式

6-(二甲基氨基)烟碱醛

2-二甲氨基吡啶结构式

2-二甲氨基吡啶

~%

6-(二甲基氨基)烟碱醛结构式

6-(二甲基氨基)烟碱醛

6-(二甲基氨基)-4-甲基烟醛结构式

6-(二甲基氨基)-4-甲基烟醛

~%

R121919结构式

5-溴-N,N,4-三甲基-2-吡啶胺结构式

5-溴-N,N,4-三甲基-2-吡啶胺

~%

R121919结构式

2-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)ACETONITRILE结构式

2-(6-(DIMETHYLA...

~%

R121919结构式

1-cyano-1-(6-dimethylamino-4-methylpyridin-3-yl)acetone结构式

1-cyano-1-(6-di...

~%

R121919结构式

3-(4-methyl-6-dimethylaminopyridin-3-yl)-2,5-dimethyl-7-hydroxypyrazolo[1,5-a]pyrimidine结构式

3-(4-methyl-6-d...

~%

R121919结构式

N,N,4-trimethylpyridin-2-amine结构式

N,N,4-trimethyl...

~%

R121919结构式

3-amino-4-(6-dimethylamino-4-methylpyridin-3-yl)-5-methylpyrazole结构式

3-amino-4-(6-di...

~%

R121919结构式