A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers

…, S Meini, M Tancredi, A Di Fenza, A Triolo…

文献索引：Galoppini, Claudia; Meini, Stefania; Tancredi, Mariella; Di Fenza, Armida; Triolo, Antonio; Quartara, Laura; Maggi, Carlo A.; Formaggio, Fernando; Toniolo, Claudio; Mazzucco, Silvia; Papini, Annamaria; Rovero, Paolo Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 409 - 414

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被引用次数: 24

摘要

Four previously reported kinin receptor peptide antagonists, including the B1 receptor- selective peptides desArg10-HOE 140 (Hd-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-d-Tic-Oic-OH) and B-9858 (H-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-d-Igl-Oic-OH), have been modified by replacement of the central tetrapeptide Pro-Hyp-Gly-Xaa with linear alkyl spacers of variable length. The analogue of desArg10-HOE 140 containing the 11-aminoundecanoic acid as ...