Tetrahedron

Spacer molecules in peptide sequences: incorporation into analogues of atrial natriuretic factor

D Boumrah, MM Campbell, S Fenner, RG Kinsman

文献索引：Boumrah, Derradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G. Tetrahedron, 1997 , vol. 53, # 20 p. 6977 - 6992

全文：HTML全文

被引用次数: 28

摘要

In the present study, 10 modified human atrial natriuretic factor (hANF) analogues were designed using solid phase synthesis. This was carried out by replacing 'alkyl or glycol'spacer with octapeptide sequence within the cyclic portion of hANF in each analogue synthesised. The unnatural amino acid spacers (1b) and (2d) have been synthesised using solution chemistry. The latter spacers were successfully incorporated into the peptide ...