Eco-friendly synthesis and antimicrobial activities of substituted-5-(1H-indol-3-yl) methylene)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione derivatives

G Thirupathi, M Venkatanarayana, PK Dubey…

文献索引：Thirupathi; Venkatanarayana; Dubey; Bharathi Kumari Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1569 - 1580

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摘要

Abstract l-Tyrosine is an efficient catalyst for the condensation of substituted indole-3- aldehydes 1 (a–d), N-methyl indole-3-aldehydes 4 (a–d), and N-ethyl indole-3-aldehydes 6 (a–d) with meldrum's acid (2) containing a cyclic active methylene group to produce 3 (a–d), 5 (a–d), and 7 (a–d), respectively, in water at room temperature for 30 min. The antimicrobial activities of 3 (a–d), 5 (a–d), and 7 (a–d) have been studied.