Organic letters

INDQ/NO, a bioreductively activated nitric oxide prodrug

K Sharma, A Iyer, K Sengupta, H Chakrapani

文献索引：Sharma, Kavita; Iyer, Aishwarya; Sengupta, Kundan; Chakrapani, Harinath Organic Letters, 2013 , vol. 15, # 11 p. 2636 - 2639

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被引用次数: 16

摘要

The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone- diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell- based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of ...