Journal of Fluorine Chemistry

Electrophilic trifluoromethylation of arenes and N-heteroarenes using hypervalent iodine reagents

MS Wiehn, EV Vinogradova, A Togni

文献索引：Wiehn, Matthias S.; Vinogradova, Ekaterina V.; Togni, Antonio Journal of Fluorine Chemistry, 2010 , vol. 131, # 9 p. 951 - 957

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被引用次数: 137

摘要

The reaction of hypervalent iodine trifluoromethylating reagents with a variety of arenes and N-heteroarenes gives access to the corresponding trifluoromethylated compounds. In comparative studies, 1-trifluoromethyl-1, 3-dihydro-3, 3-dimethyl-1, 2-benziodoxole (2) proved to be the superior to 1-trifluoromethyl-1, 2-benziodoxol-3-(1H)-one (1) for the direct aromatic trifluoromethylation. Depending on the individual substrates, additives such as ...