Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents

…, B Meibohm, JT Dalton, DD Miller…

文献索引：Amemiya, Yoshiya; Miller, Duane D.; Hsu, Fu-Lian Synthetic Communications, 1990 , vol. 20, # 16 p. 2483 - 2489

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被引用次数: 61

摘要

A series of 2-aryl-4-benzoyl-imidazoles (ABI) was synthesized as a result of structural modifications based on the previous set of 2-aryl-imidazole-4-carboxylic amide (AICA) derivatives and 4-substituted methoxylbenzoyl-aryl-thiazoles (SMART). The average IC50 of