Regioselective Synthesis of 4, 5??Diaryl??1??methyl??1H??imidazoles Including Highly Cytotoxic Derivatives by Pd??Catalyzed Direct C??5 Arylation of 1??Methyl??1H?? …

F Bellina, S Cauteruccio, A Di Fiore…

文献索引：Bellina, Fabio; Cauteruccio, Silvia; Rossi, Renzo Journal of Organic Chemistry, 2007 , vol. 72, # 22 p. 8543 - 8546

全文：HTML全文

被引用次数: 38

摘要

Abstract A general and efficient three-step procedure for the highly regioselective synthesis of 1-methyl-1H-imidazoles possessing electron-rich, electron-neutral, and/or electron- deficient aryl moieties at their 4-and 5-positions is described. The first step involves the Pd- catalyzed direct C-5 arylation of commercially available 1-methyl-1H-imidazole with aryl bromides, and the second and third steps of the sequence involve the selective C-4 ...