Highly diastereoselective alkylation of a pyroglutamate derivative with an electrophile obtained from indole. synthesis of a potential intermediate for the preparation of …
Page 1. SYNTHETIC COMMUNICATIONS, 30(12), 2143-2159 (2000) ... 78%; iii. bromide 4, -78"C, 26h, 34% diestereoisomeric ratio (anfisyn; 7:3). The synthetic strategy to transform 2a in (-)-Monatin is under investigation in our laboratory. ... HR Om. Syn. 1959,39,30. Page 17. ...