Tetrahedron letters

Total synthesis of tryprostatin A and B as well as their enantiomers

S Zhao, T Gan, P Yu, JM Cook

文献索引：Zhao, Shuo; Gan, Tong; Yu, Peng; Cook, James M. Tetrahedron Letters, 1998 , vol. 39, # 39 p. 7009 - 7012

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被引用次数: 34

摘要

Recently, tryprostatin A (la) and B (lb) have been isolated as secondary metabolites of a marine fungal strain BM939. These indoles have been shown to completely inhibit cell cycle progression of tsFT210 cells in the G2/M phase at a final concentration of 50 Ixg/mL for la and 12.5 lxg/mL for lb, respectively. 13 Tryprostatin A (la) and B (lb) contain a 2-isoprenyltryptophan moiety and a proline residue, which comprise the diketopiperazine unit. These indole alkaloids differ ...